The U.S. Preventive Services Task Force has published a final recommendation that advises against the initiation of low-dose aspirin for primary CVD prevention in adults aged 60 years or older, a D-grade recommendation.
The task force also issued a C-grade recommendation that states low-dose aspirin for primary CVD prevention should be considered on a case-by-case basis in adults aged 40 to 59 years with a 10% or greater 10-year CVD risk.

The USPSTF advises against the initiation of low-dose aspirin for primary CVD prevention in adults aged 60 years or older.